Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada1a_human 322 7.49x49 TM7 N => ThrfsTer21 frameshift 2.675e-05 3 112148 0 None None SodiumPocket MicroSwitch
ada1a_human 308 7.35x34 TM7 F => Ter stop gained 9.109e-05 11 120756 0 None None LB (hydrophobic, Van der Waals)
ada1a_human 429 C-term F => Ter stop gained 8.252e-06 1 121186 0 None None
ada1a_human 464 C-term E => ArgfsTer14 frameshift 9.022e-06 1 110838 0 None None
ada1a_human 439 C-term S => GlnfsTer39 frameshift 8.529e-06 1 117242 0 None None
ada1a_human 431 C-term Q => Ter stop gained 8.304e-06 1 120424 0 None None
ada1a_human 395 C-term C => Ter stop gained 8.237e-06 1 121406 0 None None
ada1a_human 347 C-term C => GlnfsTer49 frameshift 0.0002636 32 121410 0 None None
ada1a_human 313 7.40x39 TM7 W => Ter stop gained 8.311e-06 1 120326 0 None None
ada1a_human 312 7.39x38 TM7 F => Ter stop gained 0.0003532 5 14156 0 None None LB (hydrophobic, Van der Waals)
ada1a_human 257 ICL3 F => GlnfsTer2 frameshift 8.264e-06 1 121012 0 None None
ada1a_human 171 ECL2 E => Ter stop gained 8.329e-06 1 120068 0 None None
ada1a_human 149 4.48x48 TM4 C => Ter stop gained 8.26e-06 1 121066 0 None None
ada1a_human 63 2.41x41 TM2 Y => Ter stop gained 4.943e-05 6 121396 0 None None
ada1a_human 59 2.37x37 TM2 S => Ter stop gained 8.237e-06 1 121398 0 None None
ada1a_human 35 1.41x41 TM1 G => AlafsTer12 frameshift 8.239e-06 1 121374 0 None None
ada1a_human 465 C-term E => D missense 0.03345 3706 110796 86 nan 0.001
ada1a_human 464 C-term E => K missense 9.021e-06 1 110848 0 nan 0.787
ada1a_human 462 C-term N => K missense 9.015e-06 1 110924 0 nan 0.018
ada1a_human 460 C-term S => I missense 9.006e-06 1 111040 0 nan 0.406
ada1a_human 454 C-term V => I missense 8.958e-06 1 111634 0 1.0 0.0
ada1a_human 453 C-term K => N missense 8.95e-06 1 111730 0 nan 0.376
ada1a_human 452 C-term I => V missense 8.926e-06 1 112032 0 nan 0.009
ada1a_human 448 C-term Q => H missense 8.873e-06 1 112706 0 nan 0.001
ada1a_human 443 C-term L => P missense 8.722e-06 1 114652 0 nan 0.0
ada1a_human 440 C-term T => I missense 8.604e-06 1 116226 0 nan 0.019
ada1a_human 440 C-term T => A missense 8.596e-06 1 116330 0 nan 0.0
ada1a_human 439 C-term S => P missense 3.424e-05 4 116834 0 nan 0.004
ada1a_human 435 C-term C => S missense 8.431e-06 1 118610 0 nan 0.629
ada1a_human 433 C-term C => R missense 3.338e-05 4 119818 0 nan 0.972
ada1a_human 431 C-term Q => H missense 8.316e-06 1 120250 0 nan 0.001
ada1a_human 430 C-term L => S missense 8.289e-06 1 120648 0 nan 0.256
ada1a_human 428 C-term S => N missense 8.271e-06 1 120904 0 nan 0.001
ada1a_human 426 C-term S => N missense 8.258e-06 1 121100 0 nan 0.007
ada1a_human 425 C-term R => K missense 8.252e-06 1 121180 0 1.0 0.0
ada1a_human 423 C-term R => Q missense 1.649e-05 2 121280 0 nan 0.586
ada1a_human 422 C-term A => T missense 8.243e-06 1 121312 0 nan 0.998
ada1a_human 419 C-term C => R missense 8.241e-06 1 121338 0 nan 0.801
ada1a_human 417 C-term S => Y missense 8.24e-06 1 121360 0 nan 0.962
ada1a_human 408 C-term A => D missense 8.238e-06 1 121396 0 nan 0.556
ada1a_human 408 C-term A => G missense 1.648e-05 2 121396 0 nan 0.285
ada1a_human 408 C-term A => P missense 8.237e-06 1 121402 0 nan 0.008
ada1a_human 407 C-term S => P missense 8.237e-06 1 121402 0 nan 0.006 PTM (Phosphorylation)
ada1a_human 405 C-term R => H missense 5.766e-05 7 121404 0 nan 0.002
ada1a_human 405 C-term R => C missense 2.471e-05 3 121402 0 nan 0.526
ada1a_human 404 C-term P => T missense 8.237e-06 1 121406 0 nan 0.219
ada1a_human 403 C-term M => V missense 1.647e-05 2 121404 0 nan 0.001
ada1a_human 402 C-term S => F missense 8.237e-06 1 121406 0 nan 0.571 PTM (Phosphorylation)
ada1a_human 394 C-term V => I missense 0.000486 59 121406 0 nan 0.016
ada1a_human 392 C-term D => N missense 1.647e-05 2 121408 0 nan 0.004
ada1a_human 391 C-term T => M missense 0.0001894 23 121410 0 0.0 0.66
ada1a_human 387 C-term R => G missense 8.237e-06 1 121406 0 nan 0.223
ada1a_human 386 C-term Y => C missense 8.237e-06 1 121410 0 0.15 0.979
ada1a_human 381 C-term S => T missense 8.237e-06 1 121410 0 0.08 0.991 PTM (Phosphorylation)
ada1a_human 379 C-term V => L missense 3.295e-05 4 121412 0 0.26 0.194
ada1a_human 379 C-term V => M missense 3.295e-05 4 121412 0 nan 0.742
ada1a_human 376 C-term R => H missense 2.471e-05 3 121410 0 nan 0.847
ada1a_human 376 C-term R => C missense 4.942e-05 6 121408 0 nan 0.055
ada1a_human 375 C-term V => L missense 0.0003295 40 121410 0 0.26 0.156
ada1a_human 374 C-term M => T missense 8.236e-06 1 121412 0 0.6 0.0
ada1a_human 374 C-term M => V missense 8.237e-06 1 121408 0 0.34 0.0
ada1a_human 371 C-term H => D missense 8.237e-06 1 121408 0 0.22 0.021
ada1a_human 369 C-term G => E missense 1.648e-05 2 121396 0 0.69 0.001
ada1a_human 367 C-term V => A missense 8.237e-06 1 121404 0 0.43 0.016
ada1a_human 367 C-term V => M missense 9.061e-05 11 121406 0 0.13 0.075
ada1a_human 366 C-term A => T missense 8.237e-06 1 121398 0 0.21 0.003
ada1a_human 362 C-term P => L missense 4.942e-05 6 121406 0 0.15 0.037
ada1a_human 362 C-term P => R missense 8.237e-06 1 121406 0 0.25 0.062
ada1a_human 360 C-term L => Q missense 8.237e-06 1 121406 0 0.21 0.467
ada1a_human 359 C-term T => N missense 3.295e-05 4 121408 0 0.42 0.007
ada1a_human 357 C-term G => S missense 7.413e-05 9 121406 0 0.54 0.014
ada1a_human 356 C-term L => P missense 8.237e-06 1 121410 0 0.15 0.007
ada1a_human 355 C-term A => D missense 2.471e-05 3 121408 0 0.43 0.062
ada1a_human 352 C-term S => P missense 8.237e-06 1 121410 0 0.34 0.005 PTM (Phosphorylation)
ada1a_human 347 C-term C => Y missense 4.118e-05 5 121410 0 0.89 0.002
ada1a_human 347 C-term C => R missense 0.519 62995 121366 17551 0.4 0.0
ada1a_human 336 8.53x53 H8 A => G missense 1.648e-05 2 121386 0 0.0 0.998
ada1a_human 332 8.49x49 H8 E => K missense 8.241e-06 1 121338 0 0.0 0.998 GP (contact)
ada1a_human 331 8.48x48 H8 Q => L missense 8.242e-06 1 121332 0 0.08 0.818 GP (contact)
ada1a_human 329 7.56x56 TM7 S => A missense 8.244e-06 1 121300 0 0.13 0.759 GP (contact)
ada1a_human 321 7.48x48 TM7 I => V missense 8.259e-06 1 121082 0 0.3 0.824
ada1a_human 317 7.44x43 TM7 L => I missense 8.282e-06 1 120740 0 0.02 0.648 SodiumPocket MicroSwitch
ada1a_human 316 7.43x42 TM7 Y => C missense 8.288e-06 1 120660 0 0.0 0.998 LB (hydrophobic, Van der Waals, polar (hydrogen bond))
ada1a_human 315 7.42x41 TM7 G => R missense 6.638e-05 8 120526 0 0.0 0.997
ada1a_human 311 7.38x37 TM7 V => A missense 8.328e-06 1 120082 0 0.3 0.006
ada1a_human 307 7.34x33 TM7 V => I missense 8.371e-06 1 119464 0 0.22 0.074
ada1a_human 305 7.32x31 TM7 E => D missense 8.405e-06 1 118978 0 0.69 0.009 LB (polar (charge-assisted hydrogen bond))
ada1a_human 300 ECL3 D => N missense 8.513e-06 1 117474 0 0.33 0.008
ada1a_human 299 ECL3 P => A missense 8.538e-06 1 117122 0 0.05 0.877
ada1a_human 295 6.58x58 TM6 G => R missense 8.751e-06 1 114274 0 0.05 0.997
ada1a_human 294 6.57x57 TM6 I => M missense 8.725e-06 1 114618 0 0.03 0.93
ada1a_human 294 6.57x57 TM6 I => V missense 8.696e-06 1 115002 0 0.04 0.641
ada1a_human 293 6.56x56 TM6 P => S missense 0.0001643 19 115626 0 0.0 0.999
ada1a_human 289 6.52x52 TM6 F => S missense 8.488e-06 1 117812 0 0.0 1.0 LB (hydrophobic, Van der Waals, aromatic (edge-to-face))
ada1a_human 285 6.48x48 TM6 W => C missense 1.678e-05 2 119192 0 0.0 1.0 SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals)
ada1a_human 275 6.38x38 TM6 G => S missense 4.14e-05 5 120786 0 0.0 1.0
ada1a_human 270 6.33x33 TM6 A => E missense 8.272e-06 1 120886 0 0.0 1.0 GP (contact)
ada1a_human 266 6.29x29 TM6 R => Q missense 1.654e-05 2 120934 0 0.01 0.982 GP (contact)
ada1a_human 265 6.28x28 TM6 S => F missense 1.653e-05 2 120956 0 0.0 0.997 GP (contact)
ada1a_human 262 6.25x25 TM6 L => F missense 8.266e-06 1 120978 0 0.15 0.995 GP (contact)
ada1a_human 256 ICL3 H => D missense 8.262e-06 1 121030 0 0.03 0.842
ada1a_human 255 ICL3 T => S missense 8.262e-06 1 121042 0 0.75 0.122
ada1a_human 251 ICL3 A => G missense 3.305e-05 4 121034 0 0.36 0.005
ada1a_human 251 ICL3 A => D missense 8.262e-06 1 121034 0 0.31 0.185
ada1a_human 251 ICL3 A => T missense 8.262e-06 1 121034 0 0.73 0.006
ada1a_human 248 ICL3 M => T missense 1.653e-05 2 121026 0 0.59 0.001
ada1a_human 247 ICL3 G => R missense 0.004975 602 121010 10 0.23 0.022
ada1a_human 247 ICL3 G => R missense 8.264e-06 1 121010 0 0.23 0.022
ada1a_human 246 ICL3 S => R missense 8.265e-06 1 120992 0 0.43 0.015 PTM (Phosphorylation)
ada1a_human 246 ICL3 S => N missense 0.000157 19 121002 1 0.33 0.158 PTM (Phosphorylation)
ada1a_human 244 ICL3 G => A missense 8.267e-06 1 120966 0 0.35 0.003
ada1a_human 242 ICL3 P => L missense 1.654e-05 2 120954 0 0.29 0.244
ada1a_human 238 ICL3 R => W missense 8.273e-06 1 120882 0 0.02 0.988
ada1a_human 233 ICL3 T => M missense 8.278e-06 1 120796 0 0.06 0.85 PTM (Phosphorylation)
ada1a_human 232 ICL3 V => L missense 8.282e-06 1 120742 0 0.44 0.934
ada1a_human 227 ICL3 S => P missense 0.000771 93 120624 1 0.02 0.992 PTM (Phosphorylation)
ada1a_human 225 ICL3 D => H missense 4.979e-05 6 120514 0 0.01 0.198
ada1a_human 221 5.75x75 TM5 G => S missense 1.661e-05 2 120438 0 0.02 0.923 GP (contact)
ada1a_human 220 5.74x74 TM5 S => F missense 8.305e-06 1 120408 0 0.0 0.648 PTM (Phosphorylation) GP (contact)
ada1a_human 219 5.73x73 TM5 K => N missense 1.662e-05 2 120358 0 0.08 0.158
ada1a_human 219 5.73x73 TM5 K => R missense 8.307e-06 1 120380 0 0.27 0.004
ada1a_human 219 5.73x73 TM5 K => Q missense 5.816e-05 7 120354 0 0.05 0.029
ada1a_human 218 5.72x72 TM5 L => V missense 8.312e-06 1 120302 0 0.0 0.955 GP (contact)
ada1a_human 217 5.71x71 TM5 G => A missense 8.317e-06 1 120242 0 0.26 0.206 GP (contact)
ada1a_human 217 5.71x71 TM5 G => S missense 8.318e-06 1 120214 0 1.0 0.206 GP (contact)
ada1a_human 216 5.70x70 TM5 R => G missense 0.0002496 30 120210 0 0.0 0.899
ada1a_human 216 5.70x70 TM5 R => W missense 8.319e-06 1 120210 0 0.0 0.987
ada1a_human 215 5.69x69 TM5 S => N missense 7.487e-05 9 120208 0 0.02 0.072 GP (contact)
ada1a_human 209 5.63x63 TM5 V => M missense 8.328e-06 1 120070 0 0.01 0.964
ada1a_human 207 5.61x61 TM5 V => I missense 8.329e-06 1 120066 0 0.22 0.999 GP (contact)
ada1a_human 203 5.57x57 TM5 M => L missense 8.332e-06 1 120020 0 0.03 0.993
ada1a_human 201 5.55x55 TM5 L => V missense 8.332e-06 1 120014 0 0.11 0.999
ada1a_human 200 5.54x54 TM5 I => S missense 0.02458 2948 119946 45 0.0 1.0
ada1a_human 194 5.48x48 TM5 Y => H missense 8.359e-06 1 119626 0 0.0 1.0
ada1a_human 192 5.46x461 TM5 S => P missense 1.672e-05 2 119614 0 0.0 1.0 LB (Van der Waals)
ada1a_human 191 5.45x46 TM5 G => A missense 8.364e-06 1 119560 0 0.13 0.993
ada1a_human 191 5.45x46 TM5 G => D missense 8.364e-06 1 119560 0 0.02 0.999
ada1a_human 190 5.44x45 TM5 L => P missense 8.359e-06 1 119630 0 0.0 0.968
ada1a_human 189 5.43x44 TM5 A => E missense 2.508e-05 3 119600 0 0.0 1.0 LB (polar (hydrogen bond with backbone), Van der Waals)
ada1a_human 180 ECL2 E => G missense 8.345e-06 1 119832 0 0.03 0.924
ada1a_human 180 ECL2 E => Q missense 2.505e-05 3 119768 0 0.04 0.445
ada1a_human 179 ECL2 N => S missense 4.172e-05 5 119834 0 0.0 0.314
ada1a_human 175 ECL2 I => M missense 3.334e-05 4 119978 0 0.07 0.908
ada1a_human 173 ECL2 E => K missense 0.0001833 22 120050 1 0.04 0.971
ada1a_human 169 ECL2 A => V missense 8.319e-06 1 120200 0 0.31 0.507
ada1a_human 168 ECL2 P => L missense 1.663e-05 2 120250 0 0.0 0.916
ada1a_human 166 ECL2 R => K missense 0.002142 258 120428 0 1.0 0.015
ada1a_human 164 4.63x63 TM4 G => R missense 8.296e-06 1 120536 0 0.0 1.0
ada1a_human 163 4.62x62 TM4 F => L missense 1.659e-05 2 120558 0 0.92 0.995
ada1a_human 163 4.62x62 TM4 F => V missense 8.291e-06 1 120612 0 0.1 0.999
ada1a_human 163 4.62x62 TM4 F => L missense 8.291e-06 1 120612 0 0.92 0.995
ada1a_human 161 4.60x60 TM4 P => L missense 1.657e-05 2 120690 0 0.0 1.0
ada1a_human 161 4.60x60 TM4 P => S missense 8.286e-06 1 120690 0 0.0 1.0
ada1a_human 159 4.58x58 TM4 I => V missense 8.279e-06 1 120784 0 0.59 0.075
ada1a_human 158 4.57x57 TM4 S => A missense 8.277e-06 1 120810 0 0.01 0.998
ada1a_human 155 4.54x54 TM4 L => R missense 8.27e-06 1 120912 0 0.01 0.99
ada1a_human 154 4.53x53 TM4 S => A missense 0.006457 781 120946 7 0.19 0.812
ada1a_human 152 4.51x51 TM4 A => T missense 8.264e-06 1 121000 0 0.02 0.763
ada1a_human 148 4.47x47 TM4 L => P missense 8.258e-06 1 121098 0 0.01 0.904
ada1a_human 146 4.45x45 TM4 A => S missense 2.477e-05 3 121118 0 0.02 0.94
ada1a_human 145 4.44x44 TM4 M => I missense 8.256e-06 1 121122 0 0.21 0.006
ada1a_human 143 4.42x42 TM4 G => V missense 6.604e-05 8 121144 0 0.04 0.964
ada1a_human 138 34.57x57 ICL2 V => L missense 8.252e-06 1 121184 0 0.07 0.61 GP (contact)
ada1a_human 133 34.52x52 ICL2 R => H missense 8.25e-06 1 121216 0 0.06 0.994 GP (contact)
ada1a_human 133 34.52x52 ICL2 R => L missense 8.25e-06 1 121216 0 0.01 0.991 GP (contact)
ada1a_human 129 3.55x55 TM3 S => I missense 8.245e-06 1 121280 0 0.01 1.0 GP (contact)
ada1a_human 126 3.52x52 TM3 I => M missense 8.244e-06 1 121296 0 0.02 0.916
ada1a_human 126 3.52x52 TM3 I => N missense 3.298e-05 4 121294 0 0.0 0.992
ada1a_human 125 3.51x51 TM3 Y => C missense 8.244e-06 1 121298 0 0.01 0.978
ada1a_human 124 3.50x50 TM3 R => C missense 8.244e-06 1 121306 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
ada1a_human 122 3.48x48 TM3 I => T missense 8.243e-06 1 121322 0 0.0 0.96
ada1a_human 122 3.48x48 TM3 I => V missense 8.242e-06 1 121326 0 0.58 0.272
ada1a_human 114 3.40x40 TM3 I => T missense 8.24e-06 1 121352 0 0.0 1.0 SodiumPocket MicroSwitch
ada1a_human 113 3.39x39 TM3 S => C missense 2.472e-05 3 121358 0 0.0 1.0
ada1a_human 101 3.27x27 TM3 I => T missense 8.239e-06 1 121380 0 0.0 0.7
ada1a_human 100 3.26x26 TM3 N => K missense 1.648e-05 2 121378 0 0.0 0.672
ada1a_human 97 3.23x23 TM3 V => A missense 8.239e-06 1 121378 0 0.42 0.009
ada1a_human 97 3.23x23 TM3 V => I missense 1.648e-05 2 121384 0 1.0 0.006
ada1a_human 84 2.62x61 TM2 A => T missense 8.239e-06 1 121378 0 0.01 0.881
ada1a_human 76 2.54x54 TM2 T => I missense 8.238e-05 10 121384 0 0.0 0.898
ada1a_human 73 2.51x51 TM2 L => F missense 8.238e-06 1 121388 0 0.01 0.739
ada1a_human 72 2.50x50 TM2 D => H missense 8.238e-06 1 121386 0 0.0 1.0
ada1a_human 71 2.49x49 TM2 A => D missense 8.238e-06 1 121392 0 0.0 1.0
ada1a_human 67 2.45x45 TM2 N => S missense 8.238e-06 1 121396 0 0.04 0.999
ada1a_human 65 2.43x43 TM2 I => V missense 4.119e-05 5 121396 0 0.0 0.997
ada1a_human 55 12.48x48 ICL1 R => Q missense 5.766e-05 7 121398 0 0.01 0.925
ada1a_human 52 1.58x58 TM1 A => V missense 1.647e-05 2 121398 0 0.35 0.16
ada1a_human 51 1.57x57 TM1 V => I missense 8.237e-06 1 121406 0 0.02 1.0
ada1a_human 49 1.55x55 TM1 L => P missense 8.237e-06 1 121406 0 0.0 1.0
ada1a_human 48 1.54x54 TM1 I => N missense 3.295e-05 4 121406 0 0.0 1.0
ada1a_human 48 1.54x54 TM1 I => F missense 8.237e-06 1 121406 0 0.0 1.0
ada1a_human 48 1.54x54 TM1 I => V missense 3.295e-05 4 121406 0 0.07 0.999
ada1a_human 47 1.53x53 TM1 V => A missense 8.237e-06 1 121406 0 0.0 0.999
ada1a_human 40 1.46x46 TM1 G => R missense 1.647e-05 2 121398 0 0.0 1.0
ada1a_human 20 1.26x26 TM1 P => L missense 8.312e-06 1 120302 0 0.04 0.091
ada1a_human 20 1.26x26 TM1 P => S missense 8.313e-06 1 120288 0 0.12 0.071
ada1a_human 17 N-term P => L missense 1.672e-05 2 119628 0 0.18 0.075
ada1a_human 17 N-term P => S missense 3.356e-05 4 119196 0 0.32 0.006
ada1a_human 14 N-term C => G missense 8.421e-06 1 118746 0 0.11 0.999
ada1a_human 14 N-term C => S missense 1.684e-05 2 118746 0 0.3 0.999
ada1a_human 13 N-term N => K missense 1.687e-05 2 118524 0 0.01 0.999
ada1a_human 10 N-term D => G missense 8.54e-06 1 117098 0 0.06 0.281
ada1a_human 5 N-term S => L missense 8.698e-06 1 114966 0 nan 0.079


Residue

Diagrams

ICL1 R H L H ICL1ECL1 Y W A F ECL1ICL2 P L R Y P T I V ICL2ECL2 R Q P A P E D E T I C Q I N E ECL2ICL3 K T D K S D S E Q V T L R I H R K N A P A G G S G M A S A K T K T H F S V R ICL3ECL3 P D F K P ECL3N-term M V F L S G N A S D S S N C T Q P P A N-termC-term I Q C L C R K Q S S K H A L G Y T L H P P S Q A V E G Q H K D M V R I P V G S R E T F Y R I S K T D G V C E W K F F S S M P R G S A R I T V S K D Q S S C T T A R V R S K S F L Q V C C C V G P S T P S L D K N H Q V P T I K V H T I S L S E N G E E V C-term P V N I S K A I L L G V I L G G L I L F G V L G N I L V I L S V A C H S V T H Y Y I V N L A V A D L L L T S T V L P F S A I F E V L G G R V F C N I W A A V D V L C C T A S I M G L C I I S I D R Y I G V S Y T Q R R G L M A L L C V W A L S L V I S I G P L F G W E P G Y V L F S A L G S F Y L P L A I I L V M Y C R V Y V V A K R E S R G L K S G L L L K F S R E K K A A K T L G I V V G C F V L C W L P F F L V M P I G S F F S E T V F K I V F W L G Y L N S C I N P I I Y P C S S Q E F Q N F K K A V L R
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