Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
ada1a_human | 322 | 7.49x49 | TM7 | N => ThrfsTer21 | frameshift | 2.675e-05 | 3 | 112148 | 0 | None | None | SodiumPocket MicroSwitch |
ada1a_human | 308 | 7.35x34 | TM7 | F => Ter | stop gained | 9.109e-05 | 11 | 120756 | 0 | None | None | LB (hydrophobic, Van der Waals) |
ada1a_human | 429 | C-term | F => Ter | stop gained | 8.252e-06 | 1 | 121186 | 0 | None | None | ||
ada1a_human | 464 | C-term | E => ArgfsTer14 | frameshift | 9.022e-06 | 1 | 110838 | 0 | None | None | ||
ada1a_human | 439 | C-term | S => GlnfsTer39 | frameshift | 8.529e-06 | 1 | 117242 | 0 | None | None | ||
ada1a_human | 431 | C-term | Q => Ter | stop gained | 8.304e-06 | 1 | 120424 | 0 | None | None | ||
ada1a_human | 395 | C-term | C => Ter | stop gained | 8.237e-06 | 1 | 121406 | 0 | None | None | ||
ada1a_human | 347 | C-term | C => GlnfsTer49 | frameshift | 0.0002636 | 32 | 121410 | 0 | None | None | ||
ada1a_human | 313 | 7.40x39 | TM7 | W => Ter | stop gained | 8.311e-06 | 1 | 120326 | 0 | None | None | |
ada1a_human | 312 | 7.39x38 | TM7 | F => Ter | stop gained | 0.0003532 | 5 | 14156 | 0 | None | None | LB (hydrophobic, Van der Waals) |
ada1a_human | 257 | ICL3 | F => GlnfsTer2 | frameshift | 8.264e-06 | 1 | 121012 | 0 | None | None | ||
ada1a_human | 171 | ECL2 | E => Ter | stop gained | 8.329e-06 | 1 | 120068 | 0 | None | None | ||
ada1a_human | 149 | 4.48x48 | TM4 | C => Ter | stop gained | 8.26e-06 | 1 | 121066 | 0 | None | None | |
ada1a_human | 63 | 2.41x41 | TM2 | Y => Ter | stop gained | 4.943e-05 | 6 | 121396 | 0 | None | None | |
ada1a_human | 59 | 2.37x37 | TM2 | S => Ter | stop gained | 8.237e-06 | 1 | 121398 | 0 | None | None | |
ada1a_human | 35 | 1.41x41 | TM1 | G => AlafsTer12 | frameshift | 8.239e-06 | 1 | 121374 | 0 | None | None | |
ada1a_human | 465 | C-term | E => D | missense | 0.03345 | 3706 | 110796 | 86 | nan | 0.001 | ||
ada1a_human | 464 | C-term | E => K | missense | 9.021e-06 | 1 | 110848 | 0 | nan | 0.787 | ||
ada1a_human | 462 | C-term | N => K | missense | 9.015e-06 | 1 | 110924 | 0 | nan | 0.018 | ||
ada1a_human | 460 | C-term | S => I | missense | 9.006e-06 | 1 | 111040 | 0 | nan | 0.406 | ||
ada1a_human | 454 | C-term | V => I | missense | 8.958e-06 | 1 | 111634 | 0 | 1.0 | 0.0 | ||
ada1a_human | 453 | C-term | K => N | missense | 8.95e-06 | 1 | 111730 | 0 | nan | 0.376 | ||
ada1a_human | 452 | C-term | I => V | missense | 8.926e-06 | 1 | 112032 | 0 | nan | 0.009 | ||
ada1a_human | 448 | C-term | Q => H | missense | 8.873e-06 | 1 | 112706 | 0 | nan | 0.001 | ||
ada1a_human | 443 | C-term | L => P | missense | 8.722e-06 | 1 | 114652 | 0 | nan | 0.0 | ||
ada1a_human | 440 | C-term | T => I | missense | 8.604e-06 | 1 | 116226 | 0 | nan | 0.019 | ||
ada1a_human | 440 | C-term | T => A | missense | 8.596e-06 | 1 | 116330 | 0 | nan | 0.0 | ||
ada1a_human | 439 | C-term | S => P | missense | 3.424e-05 | 4 | 116834 | 0 | nan | 0.004 | ||
ada1a_human | 435 | C-term | C => S | missense | 8.431e-06 | 1 | 118610 | 0 | nan | 0.629 | ||
ada1a_human | 433 | C-term | C => R | missense | 3.338e-05 | 4 | 119818 | 0 | nan | 0.972 | ||
ada1a_human | 431 | C-term | Q => H | missense | 8.316e-06 | 1 | 120250 | 0 | nan | 0.001 | ||
ada1a_human | 430 | C-term | L => S | missense | 8.289e-06 | 1 | 120648 | 0 | nan | 0.256 | ||
ada1a_human | 428 | C-term | S => N | missense | 8.271e-06 | 1 | 120904 | 0 | nan | 0.001 | ||
ada1a_human | 426 | C-term | S => N | missense | 8.258e-06 | 1 | 121100 | 0 | nan | 0.007 | ||
ada1a_human | 425 | C-term | R => K | missense | 8.252e-06 | 1 | 121180 | 0 | 1.0 | 0.0 | ||
ada1a_human | 423 | C-term | R => Q | missense | 1.649e-05 | 2 | 121280 | 0 | nan | 0.586 | ||
ada1a_human | 422 | C-term | A => T | missense | 8.243e-06 | 1 | 121312 | 0 | nan | 0.998 | ||
ada1a_human | 419 | C-term | C => R | missense | 8.241e-06 | 1 | 121338 | 0 | nan | 0.801 | ||
ada1a_human | 417 | C-term | S => Y | missense | 8.24e-06 | 1 | 121360 | 0 | nan | 0.962 | ||
ada1a_human | 408 | C-term | A => D | missense | 8.238e-06 | 1 | 121396 | 0 | nan | 0.556 | ||
ada1a_human | 408 | C-term | A => G | missense | 1.648e-05 | 2 | 121396 | 0 | nan | 0.285 | ||
ada1a_human | 408 | C-term | A => P | missense | 8.237e-06 | 1 | 121402 | 0 | nan | 0.008 | ||
ada1a_human | 407 | C-term | S => P | missense | 8.237e-06 | 1 | 121402 | 0 | nan | 0.006 | PTM (Phosphorylation) | |
ada1a_human | 405 | C-term | R => H | missense | 5.766e-05 | 7 | 121404 | 0 | nan | 0.002 | ||
ada1a_human | 405 | C-term | R => C | missense | 2.471e-05 | 3 | 121402 | 0 | nan | 0.526 | ||
ada1a_human | 404 | C-term | P => T | missense | 8.237e-06 | 1 | 121406 | 0 | nan | 0.219 | ||
ada1a_human | 403 | C-term | M => V | missense | 1.647e-05 | 2 | 121404 | 0 | nan | 0.001 | ||
ada1a_human | 402 | C-term | S => F | missense | 8.237e-06 | 1 | 121406 | 0 | nan | 0.571 | PTM (Phosphorylation) | |
ada1a_human | 394 | C-term | V => I | missense | 0.000486 | 59 | 121406 | 0 | nan | 0.016 | ||
ada1a_human | 392 | C-term | D => N | missense | 1.647e-05 | 2 | 121408 | 0 | nan | 0.004 | ||
ada1a_human | 391 | C-term | T => M | missense | 0.0001894 | 23 | 121410 | 0 | 0.0 | 0.66 | ||
ada1a_human | 387 | C-term | R => G | missense | 8.237e-06 | 1 | 121406 | 0 | nan | 0.223 | ||
ada1a_human | 386 | C-term | Y => C | missense | 8.237e-06 | 1 | 121410 | 0 | 0.15 | 0.979 | ||
ada1a_human | 381 | C-term | S => T | missense | 8.237e-06 | 1 | 121410 | 0 | 0.08 | 0.991 | PTM (Phosphorylation) | |
ada1a_human | 379 | C-term | V => L | missense | 3.295e-05 | 4 | 121412 | 0 | 0.26 | 0.194 | ||
ada1a_human | 379 | C-term | V => M | missense | 3.295e-05 | 4 | 121412 | 0 | nan | 0.742 | ||
ada1a_human | 376 | C-term | R => H | missense | 2.471e-05 | 3 | 121410 | 0 | nan | 0.847 | ||
ada1a_human | 376 | C-term | R => C | missense | 4.942e-05 | 6 | 121408 | 0 | nan | 0.055 | ||
ada1a_human | 375 | C-term | V => L | missense | 0.0003295 | 40 | 121410 | 0 | 0.26 | 0.156 | ||
ada1a_human | 374 | C-term | M => T | missense | 8.236e-06 | 1 | 121412 | 0 | 0.6 | 0.0 | ||
ada1a_human | 374 | C-term | M => V | missense | 8.237e-06 | 1 | 121408 | 0 | 0.34 | 0.0 | ||
ada1a_human | 371 | C-term | H => D | missense | 8.237e-06 | 1 | 121408 | 0 | 0.22 | 0.021 | ||
ada1a_human | 369 | C-term | G => E | missense | 1.648e-05 | 2 | 121396 | 0 | 0.69 | 0.001 | ||
ada1a_human | 367 | C-term | V => A | missense | 8.237e-06 | 1 | 121404 | 0 | 0.43 | 0.016 | ||
ada1a_human | 367 | C-term | V => M | missense | 9.061e-05 | 11 | 121406 | 0 | 0.13 | 0.075 | ||
ada1a_human | 366 | C-term | A => T | missense | 8.237e-06 | 1 | 121398 | 0 | 0.21 | 0.003 | ||
ada1a_human | 362 | C-term | P => L | missense | 4.942e-05 | 6 | 121406 | 0 | 0.15 | 0.037 | ||
ada1a_human | 362 | C-term | P => R | missense | 8.237e-06 | 1 | 121406 | 0 | 0.25 | 0.062 | ||
ada1a_human | 360 | C-term | L => Q | missense | 8.237e-06 | 1 | 121406 | 0 | 0.21 | 0.467 | ||
ada1a_human | 359 | C-term | T => N | missense | 3.295e-05 | 4 | 121408 | 0 | 0.42 | 0.007 | ||
ada1a_human | 357 | C-term | G => S | missense | 7.413e-05 | 9 | 121406 | 0 | 0.54 | 0.014 | ||
ada1a_human | 356 | C-term | L => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.15 | 0.007 | ||
ada1a_human | 355 | C-term | A => D | missense | 2.471e-05 | 3 | 121408 | 0 | 0.43 | 0.062 | ||
ada1a_human | 352 | C-term | S => P | missense | 8.237e-06 | 1 | 121410 | 0 | 0.34 | 0.005 | PTM (Phosphorylation) | |
ada1a_human | 347 | C-term | C => Y | missense | 4.118e-05 | 5 | 121410 | 0 | 0.89 | 0.002 | ||
ada1a_human | 347 | C-term | C => R | missense | 0.519 | 62995 | 121366 | 17551 | 0.4 | 0.0 | ||
ada1a_human | 336 | 8.53x53 | H8 | A => G | missense | 1.648e-05 | 2 | 121386 | 0 | 0.0 | 0.998 | |
ada1a_human | 332 | 8.49x49 | H8 | E => K | missense | 8.241e-06 | 1 | 121338 | 0 | 0.0 | 0.998 | GP (contact) |
ada1a_human | 331 | 8.48x48 | H8 | Q => L | missense | 8.242e-06 | 1 | 121332 | 0 | 0.08 | 0.818 | GP (contact) |
ada1a_human | 329 | 7.56x56 | TM7 | S => A | missense | 8.244e-06 | 1 | 121300 | 0 | 0.13 | 0.759 | GP (contact) |
ada1a_human | 321 | 7.48x48 | TM7 | I => V | missense | 8.259e-06 | 1 | 121082 | 0 | 0.3 | 0.824 | |
ada1a_human | 317 | 7.44x43 | TM7 | L => I | missense | 8.282e-06 | 1 | 120740 | 0 | 0.02 | 0.648 | SodiumPocket MicroSwitch |
ada1a_human | 316 | 7.43x42 | TM7 | Y => C | missense | 8.288e-06 | 1 | 120660 | 0 | 0.0 | 0.998 | LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
ada1a_human | 315 | 7.42x41 | TM7 | G => R | missense | 6.638e-05 | 8 | 120526 | 0 | 0.0 | 0.997 | |
ada1a_human | 311 | 7.38x37 | TM7 | V => A | missense | 8.328e-06 | 1 | 120082 | 0 | 0.3 | 0.006 | |
ada1a_human | 307 | 7.34x33 | TM7 | V => I | missense | 8.371e-06 | 1 | 119464 | 0 | 0.22 | 0.074 | |
ada1a_human | 305 | 7.32x31 | TM7 | E => D | missense | 8.405e-06 | 1 | 118978 | 0 | 0.69 | 0.009 | LB (polar (charge-assisted hydrogen bond)) |
ada1a_human | 300 | ECL3 | D => N | missense | 8.513e-06 | 1 | 117474 | 0 | 0.33 | 0.008 | ||
ada1a_human | 299 | ECL3 | P => A | missense | 8.538e-06 | 1 | 117122 | 0 | 0.05 | 0.877 | ||
ada1a_human | 295 | 6.58x58 | TM6 | G => R | missense | 8.751e-06 | 1 | 114274 | 0 | 0.05 | 0.997 | |
ada1a_human | 294 | 6.57x57 | TM6 | I => M | missense | 8.725e-06 | 1 | 114618 | 0 | 0.03 | 0.93 | |
ada1a_human | 294 | 6.57x57 | TM6 | I => V | missense | 8.696e-06 | 1 | 115002 | 0 | 0.04 | 0.641 | |
ada1a_human | 293 | 6.56x56 | TM6 | P => S | missense | 0.0001643 | 19 | 115626 | 0 | 0.0 | 0.999 | |
ada1a_human | 289 | 6.52x52 | TM6 | F => S | missense | 8.488e-06 | 1 | 117812 | 0 | 0.0 | 1.0 | LB (hydrophobic, Van der Waals, aromatic (edge-to-face)) |
ada1a_human | 285 | 6.48x48 | TM6 | W => C | missense | 1.678e-05 | 2 | 119192 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals) |
ada1a_human | 275 | 6.38x38 | TM6 | G => S | missense | 4.14e-05 | 5 | 120786 | 0 | 0.0 | 1.0 | |
ada1a_human | 270 | 6.33x33 | TM6 | A => E | missense | 8.272e-06 | 1 | 120886 | 0 | 0.0 | 1.0 | GP (contact) |
ada1a_human | 266 | 6.29x29 | TM6 | R => Q | missense | 1.654e-05 | 2 | 120934 | 0 | 0.01 | 0.982 | GP (contact) |
ada1a_human | 265 | 6.28x28 | TM6 | S => F | missense | 1.653e-05 | 2 | 120956 | 0 | 0.0 | 0.997 | GP (contact) |
ada1a_human | 262 | 6.25x25 | TM6 | L => F | missense | 8.266e-06 | 1 | 120978 | 0 | 0.15 | 0.995 | GP (contact) |
ada1a_human | 256 | ICL3 | H => D | missense | 8.262e-06 | 1 | 121030 | 0 | 0.03 | 0.842 | ||
ada1a_human | 255 | ICL3 | T => S | missense | 8.262e-06 | 1 | 121042 | 0 | 0.75 | 0.122 | ||
ada1a_human | 251 | ICL3 | A => G | missense | 3.305e-05 | 4 | 121034 | 0 | 0.36 | 0.005 | ||
ada1a_human | 251 | ICL3 | A => D | missense | 8.262e-06 | 1 | 121034 | 0 | 0.31 | 0.185 | ||
ada1a_human | 251 | ICL3 | A => T | missense | 8.262e-06 | 1 | 121034 | 0 | 0.73 | 0.006 | ||
ada1a_human | 248 | ICL3 | M => T | missense | 1.653e-05 | 2 | 121026 | 0 | 0.59 | 0.001 | ||
ada1a_human | 247 | ICL3 | G => R | missense | 0.004975 | 602 | 121010 | 10 | 0.23 | 0.022 | ||
ada1a_human | 247 | ICL3 | G => R | missense | 8.264e-06 | 1 | 121010 | 0 | 0.23 | 0.022 | ||
ada1a_human | 246 | ICL3 | S => R | missense | 8.265e-06 | 1 | 120992 | 0 | 0.43 | 0.015 | PTM (Phosphorylation) | |
ada1a_human | 246 | ICL3 | S => N | missense | 0.000157 | 19 | 121002 | 1 | 0.33 | 0.158 | PTM (Phosphorylation) | |
ada1a_human | 244 | ICL3 | G => A | missense | 8.267e-06 | 1 | 120966 | 0 | 0.35 | 0.003 | ||
ada1a_human | 242 | ICL3 | P => L | missense | 1.654e-05 | 2 | 120954 | 0 | 0.29 | 0.244 | ||
ada1a_human | 238 | ICL3 | R => W | missense | 8.273e-06 | 1 | 120882 | 0 | 0.02 | 0.988 | ||
ada1a_human | 233 | ICL3 | T => M | missense | 8.278e-06 | 1 | 120796 | 0 | 0.06 | 0.85 | PTM (Phosphorylation) | |
ada1a_human | 232 | ICL3 | V => L | missense | 8.282e-06 | 1 | 120742 | 0 | 0.44 | 0.934 | ||
ada1a_human | 227 | ICL3 | S => P | missense | 0.000771 | 93 | 120624 | 1 | 0.02 | 0.992 | PTM (Phosphorylation) | |
ada1a_human | 225 | ICL3 | D => H | missense | 4.979e-05 | 6 | 120514 | 0 | 0.01 | 0.198 | ||
ada1a_human | 221 | 5.75x75 | TM5 | G => S | missense | 1.661e-05 | 2 | 120438 | 0 | 0.02 | 0.923 | GP (contact) |
ada1a_human | 220 | 5.74x74 | TM5 | S => F | missense | 8.305e-06 | 1 | 120408 | 0 | 0.0 | 0.648 | PTM (Phosphorylation) GP (contact) |
ada1a_human | 219 | 5.73x73 | TM5 | K => N | missense | 1.662e-05 | 2 | 120358 | 0 | 0.08 | 0.158 | |
ada1a_human | 219 | 5.73x73 | TM5 | K => R | missense | 8.307e-06 | 1 | 120380 | 0 | 0.27 | 0.004 | |
ada1a_human | 219 | 5.73x73 | TM5 | K => Q | missense | 5.816e-05 | 7 | 120354 | 0 | 0.05 | 0.029 | |
ada1a_human | 218 | 5.72x72 | TM5 | L => V | missense | 8.312e-06 | 1 | 120302 | 0 | 0.0 | 0.955 | GP (contact) |
ada1a_human | 217 | 5.71x71 | TM5 | G => A | missense | 8.317e-06 | 1 | 120242 | 0 | 0.26 | 0.206 | GP (contact) |
ada1a_human | 217 | 5.71x71 | TM5 | G => S | missense | 8.318e-06 | 1 | 120214 | 0 | 1.0 | 0.206 | GP (contact) |
ada1a_human | 216 | 5.70x70 | TM5 | R => G | missense | 0.0002496 | 30 | 120210 | 0 | 0.0 | 0.899 | |
ada1a_human | 216 | 5.70x70 | TM5 | R => W | missense | 8.319e-06 | 1 | 120210 | 0 | 0.0 | 0.987 | |
ada1a_human | 215 | 5.69x69 | TM5 | S => N | missense | 7.487e-05 | 9 | 120208 | 0 | 0.02 | 0.072 | GP (contact) |
ada1a_human | 209 | 5.63x63 | TM5 | V => M | missense | 8.328e-06 | 1 | 120070 | 0 | 0.01 | 0.964 | |
ada1a_human | 207 | 5.61x61 | TM5 | V => I | missense | 8.329e-06 | 1 | 120066 | 0 | 0.22 | 0.999 | GP (contact) |
ada1a_human | 203 | 5.57x57 | TM5 | M => L | missense | 8.332e-06 | 1 | 120020 | 0 | 0.03 | 0.993 | |
ada1a_human | 201 | 5.55x55 | TM5 | L => V | missense | 8.332e-06 | 1 | 120014 | 0 | 0.11 | 0.999 | |
ada1a_human | 200 | 5.54x54 | TM5 | I => S | missense | 0.02458 | 2948 | 119946 | 45 | 0.0 | 1.0 | |
ada1a_human | 194 | 5.48x48 | TM5 | Y => H | missense | 8.359e-06 | 1 | 119626 | 0 | 0.0 | 1.0 | |
ada1a_human | 192 | 5.46x461 | TM5 | S => P | missense | 1.672e-05 | 2 | 119614 | 0 | 0.0 | 1.0 | LB (Van der Waals) |
ada1a_human | 191 | 5.45x46 | TM5 | G => A | missense | 8.364e-06 | 1 | 119560 | 0 | 0.13 | 0.993 | |
ada1a_human | 191 | 5.45x46 | TM5 | G => D | missense | 8.364e-06 | 1 | 119560 | 0 | 0.02 | 0.999 | |
ada1a_human | 190 | 5.44x45 | TM5 | L => P | missense | 8.359e-06 | 1 | 119630 | 0 | 0.0 | 0.968 | |
ada1a_human | 189 | 5.43x44 | TM5 | A => E | missense | 2.508e-05 | 3 | 119600 | 0 | 0.0 | 1.0 | LB (polar (hydrogen bond with backbone), Van der Waals) |
ada1a_human | 180 | ECL2 | E => G | missense | 8.345e-06 | 1 | 119832 | 0 | 0.03 | 0.924 | ||
ada1a_human | 180 | ECL2 | E => Q | missense | 2.505e-05 | 3 | 119768 | 0 | 0.04 | 0.445 | ||
ada1a_human | 179 | ECL2 | N => S | missense | 4.172e-05 | 5 | 119834 | 0 | 0.0 | 0.314 | ||
ada1a_human | 175 | ECL2 | I => M | missense | 3.334e-05 | 4 | 119978 | 0 | 0.07 | 0.908 | ||
ada1a_human | 173 | ECL2 | E => K | missense | 0.0001833 | 22 | 120050 | 1 | 0.04 | 0.971 | ||
ada1a_human | 169 | ECL2 | A => V | missense | 8.319e-06 | 1 | 120200 | 0 | 0.31 | 0.507 | ||
ada1a_human | 168 | ECL2 | P => L | missense | 1.663e-05 | 2 | 120250 | 0 | 0.0 | 0.916 | ||
ada1a_human | 166 | ECL2 | R => K | missense | 0.002142 | 258 | 120428 | 0 | 1.0 | 0.015 | ||
ada1a_human | 164 | 4.63x63 | TM4 | G => R | missense | 8.296e-06 | 1 | 120536 | 0 | 0.0 | 1.0 | |
ada1a_human | 163 | 4.62x62 | TM4 | F => L | missense | 1.659e-05 | 2 | 120558 | 0 | 0.92 | 0.995 | |
ada1a_human | 163 | 4.62x62 | TM4 | F => V | missense | 8.291e-06 | 1 | 120612 | 0 | 0.1 | 0.999 | |
ada1a_human | 163 | 4.62x62 | TM4 | F => L | missense | 8.291e-06 | 1 | 120612 | 0 | 0.92 | 0.995 | |
ada1a_human | 161 | 4.60x60 | TM4 | P => L | missense | 1.657e-05 | 2 | 120690 | 0 | 0.0 | 1.0 | |
ada1a_human | 161 | 4.60x60 | TM4 | P => S | missense | 8.286e-06 | 1 | 120690 | 0 | 0.0 | 1.0 | |
ada1a_human | 159 | 4.58x58 | TM4 | I => V | missense | 8.279e-06 | 1 | 120784 | 0 | 0.59 | 0.075 | |
ada1a_human | 158 | 4.57x57 | TM4 | S => A | missense | 8.277e-06 | 1 | 120810 | 0 | 0.01 | 0.998 | |
ada1a_human | 155 | 4.54x54 | TM4 | L => R | missense | 8.27e-06 | 1 | 120912 | 0 | 0.01 | 0.99 | |
ada1a_human | 154 | 4.53x53 | TM4 | S => A | missense | 0.006457 | 781 | 120946 | 7 | 0.19 | 0.812 | |
ada1a_human | 152 | 4.51x51 | TM4 | A => T | missense | 8.264e-06 | 1 | 121000 | 0 | 0.02 | 0.763 | |
ada1a_human | 148 | 4.47x47 | TM4 | L => P | missense | 8.258e-06 | 1 | 121098 | 0 | 0.01 | 0.904 | |
ada1a_human | 146 | 4.45x45 | TM4 | A => S | missense | 2.477e-05 | 3 | 121118 | 0 | 0.02 | 0.94 | |
ada1a_human | 145 | 4.44x44 | TM4 | M => I | missense | 8.256e-06 | 1 | 121122 | 0 | 0.21 | 0.006 | |
ada1a_human | 143 | 4.42x42 | TM4 | G => V | missense | 6.604e-05 | 8 | 121144 | 0 | 0.04 | 0.964 | |
ada1a_human | 138 | 34.57x57 | ICL2 | V => L | missense | 8.252e-06 | 1 | 121184 | 0 | 0.07 | 0.61 | GP (contact) |
ada1a_human | 133 | 34.52x52 | ICL2 | R => H | missense | 8.25e-06 | 1 | 121216 | 0 | 0.06 | 0.994 | GP (contact) |
ada1a_human | 133 | 34.52x52 | ICL2 | R => L | missense | 8.25e-06 | 1 | 121216 | 0 | 0.01 | 0.991 | GP (contact) |
ada1a_human | 129 | 3.55x55 | TM3 | S => I | missense | 8.245e-06 | 1 | 121280 | 0 | 0.01 | 1.0 | GP (contact) |
ada1a_human | 126 | 3.52x52 | TM3 | I => M | missense | 8.244e-06 | 1 | 121296 | 0 | 0.02 | 0.916 | |
ada1a_human | 126 | 3.52x52 | TM3 | I => N | missense | 3.298e-05 | 4 | 121294 | 0 | 0.0 | 0.992 | |
ada1a_human | 125 | 3.51x51 | TM3 | Y => C | missense | 8.244e-06 | 1 | 121298 | 0 | 0.01 | 0.978 | |
ada1a_human | 124 | 3.50x50 | TM3 | R => C | missense | 8.244e-06 | 1 | 121306 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
ada1a_human | 122 | 3.48x48 | TM3 | I => T | missense | 8.243e-06 | 1 | 121322 | 0 | 0.0 | 0.96 | |
ada1a_human | 122 | 3.48x48 | TM3 | I => V | missense | 8.242e-06 | 1 | 121326 | 0 | 0.58 | 0.272 | |
ada1a_human | 114 | 3.40x40 | TM3 | I => T | missense | 8.24e-06 | 1 | 121352 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
ada1a_human | 113 | 3.39x39 | TM3 | S => C | missense | 2.472e-05 | 3 | 121358 | 0 | 0.0 | 1.0 | |
ada1a_human | 101 | 3.27x27 | TM3 | I => T | missense | 8.239e-06 | 1 | 121380 | 0 | 0.0 | 0.7 | |
ada1a_human | 100 | 3.26x26 | TM3 | N => K | missense | 1.648e-05 | 2 | 121378 | 0 | 0.0 | 0.672 | |
ada1a_human | 97 | 3.23x23 | TM3 | V => A | missense | 8.239e-06 | 1 | 121378 | 0 | 0.42 | 0.009 | |
ada1a_human | 97 | 3.23x23 | TM3 | V => I | missense | 1.648e-05 | 2 | 121384 | 0 | 1.0 | 0.006 | |
ada1a_human | 84 | 2.62x61 | TM2 | A => T | missense | 8.239e-06 | 1 | 121378 | 0 | 0.01 | 0.881 | |
ada1a_human | 76 | 2.54x54 | TM2 | T => I | missense | 8.238e-05 | 10 | 121384 | 0 | 0.0 | 0.898 | |
ada1a_human | 73 | 2.51x51 | TM2 | L => F | missense | 8.238e-06 | 1 | 121388 | 0 | 0.01 | 0.739 | |
ada1a_human | 72 | 2.50x50 | TM2 | D => H | missense | 8.238e-06 | 1 | 121386 | 0 | 0.0 | 1.0 | |
ada1a_human | 71 | 2.49x49 | TM2 | A => D | missense | 8.238e-06 | 1 | 121392 | 0 | 0.0 | 1.0 | |
ada1a_human | 67 | 2.45x45 | TM2 | N => S | missense | 8.238e-06 | 1 | 121396 | 0 | 0.04 | 0.999 | |
ada1a_human | 65 | 2.43x43 | TM2 | I => V | missense | 4.119e-05 | 5 | 121396 | 0 | 0.0 | 0.997 | |
ada1a_human | 55 | 12.48x48 | ICL1 | R => Q | missense | 5.766e-05 | 7 | 121398 | 0 | 0.01 | 0.925 | |
ada1a_human | 52 | 1.58x58 | TM1 | A => V | missense | 1.647e-05 | 2 | 121398 | 0 | 0.35 | 0.16 | |
ada1a_human | 51 | 1.57x57 | TM1 | V => I | missense | 8.237e-06 | 1 | 121406 | 0 | 0.02 | 1.0 | |
ada1a_human | 49 | 1.55x55 | TM1 | L => P | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 1.0 | |
ada1a_human | 48 | 1.54x54 | TM1 | I => N | missense | 3.295e-05 | 4 | 121406 | 0 | 0.0 | 1.0 | |
ada1a_human | 48 | 1.54x54 | TM1 | I => F | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 1.0 | |
ada1a_human | 48 | 1.54x54 | TM1 | I => V | missense | 3.295e-05 | 4 | 121406 | 0 | 0.07 | 0.999 | |
ada1a_human | 47 | 1.53x53 | TM1 | V => A | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.999 | |
ada1a_human | 40 | 1.46x46 | TM1 | G => R | missense | 1.647e-05 | 2 | 121398 | 0 | 0.0 | 1.0 | |
ada1a_human | 20 | 1.26x26 | TM1 | P => L | missense | 8.312e-06 | 1 | 120302 | 0 | 0.04 | 0.091 | |
ada1a_human | 20 | 1.26x26 | TM1 | P => S | missense | 8.313e-06 | 1 | 120288 | 0 | 0.12 | 0.071 | |
ada1a_human | 17 | N-term | P => L | missense | 1.672e-05 | 2 | 119628 | 0 | 0.18 | 0.075 | ||
ada1a_human | 17 | N-term | P => S | missense | 3.356e-05 | 4 | 119196 | 0 | 0.32 | 0.006 | ||
ada1a_human | 14 | N-term | C => G | missense | 8.421e-06 | 1 | 118746 | 0 | 0.11 | 0.999 | ||
ada1a_human | 14 | N-term | C => S | missense | 1.684e-05 | 2 | 118746 | 0 | 0.3 | 0.999 | ||
ada1a_human | 13 | N-term | N => K | missense | 1.687e-05 | 2 | 118524 | 0 | 0.01 | 0.999 | ||
ada1a_human | 10 | N-term | D => G | missense | 8.54e-06 | 1 | 117098 | 0 | 0.06 | 0.281 | ||
ada1a_human | 5 | N-term | S => L | missense | 8.698e-06 | 1 | 114966 | 0 | nan | 0.079 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue